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It’s particularly helpful for Parkinson’s and schizophrenia patients who also have depression (14).

SAM-e should not be mixed with drugs that affect serotonin release such as levodopa, Demerol, or Ultram, or the over-the-counter cough remedy Robitussin DM (15).

If this is your situation, here are some serotonin supplements proven to help increase serotonin levels naturally.

There are many kinds of nutritional supplements that increase serotonin levels — amino acids, vitamins, minerals, herbs, and more.

Before you take any serotonin supplement, it’s important to understand a little bit about them and especially how they work together.

Sometimes there are vital synergistic relationships between these various serotonin boosting substances.

Three of the most widely used serotonin supplements are the amino acids tryptophan, 5-HTP, and SAM-e.

Note that it is not considered safe to mix any of these amino acid supplements with antidepressant medications (4).

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For decades, manufacturers shied away from selling this supplement, but it’s now readily available and widely known to be safe.Several other brain-related disorders besides depression are related to low serotonin, including autism, ADHD, bipolar disorder, sleep disorders, and schizophrenia (3).Many people with depression or other serotonin deficiency symptoms and conditions are searching for better ways to increase serotonin levels naturally without the use of drugs.A review of 108 studies on 5-HTP revealed there is still no definitive evidence that it helps depression (9). An Ongoing Debate: There’s an ongoing discussion in the natural health community whether it’s better to take tryptophan or 5-HTP to increase serotonin levels.Tryptophan more readily enters the brain, but 5-HTP requires one less step to convert into serotonin.

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